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Advances in cancer prevention, detection, and therapy depend on understanding cellular function on the molecular level. Researchers interested in developing agents for early cancer detection by non-invasive molecular imaging and drugs for therapeutic intervention benefit from a modern understanding of genes and their regulation, as well as protein structures and their functions. To take full advantage of this knowledge, The University of Arizona Cancer Center researchers must be able to predict and ultimately control molecular interactions between small and large molecules. The activities of the former Molecular Modeling Shared Service (MMSS) and the former Synthetic Chemistry Shared Service (SCSS) supported such drug development activities, often in a synergistic fashion. Modeling permits identification of lead compounds, and synthesis provides access to small molecules of interest for biological studies. Such studies lead to structure-activity relationships (SARs) that permit recursive refinement of a lead structure with the aim of producing compounds that are true drug candidates.
In 2009, the MMSS and the SCSS were combined to form the Molecular Modeling and Synthetic Chemistry Shared Service (MMSCSS). When a seamless interface between modeling and synthesis is needed to support a Cancer Center research project, the modeling and synthesis groups work in close concert. When a Cancer Center project requires only modeling or synthetic support, the modeling, and synthetic components of the MMSCSS act independently.
We invite you to view the following web pages describing the capabilities of the MMSC Shared Service, and to contact MMSCSS personnel to discuss how we can support your AZCC research project.