Important aspects of early preclinical drug development are acute toxicity and pharmacokinetic studies. The EMSS Xenograft Team offers basic services in bioavailability, pharmacokinetics, and toxicity analysis.
Toxicology studies can include any or all of the following:
• Timed agent dosing and sampling
• Tissue and/or organ preservation
• Plasma and/or serum sampling
• Histology and pathology
• Complete Blood Counts with differentials
Pharmacokinetic sampling can be designed as a stand alone experiment, or it can be included into your therapeutic agent efficacy design. The EMSS works in collaboration with the Analytical Core Shared Service for design and analysis of the pharmacokinetic samples.