The Experimental Mouse Shared Service (EMSS) has been providing services to The University of Arizona Cancer Center and outside investigators since 1993. The EMSS provides a continuum of services, which range from in vivo experimental design, to GEM Production, to Mouse Experimentation. This enables the Cancer Center investigator to generate and use mouse models of human cancer to their fullest potential without the investigator having to be an expert on mouse genetic engineering or mouse experimentation techniques in either the GEM or the xenograft models. These are utilized so that cancer therapies can be developed efficiently, cost effectively and clinically relevant.
The Mouse Experimentation unit is located in The University of Arizona Cancer Center and led by Natalia Ignatenko, PhD.
The GEM Production unit is located in the Bio5 Institute and is led by
Tom Doetschman, PhD. The GEM manager is Phil Sanford, PhD.
The EMSS uses in vivo models to complete preclinical research and evaluate anti-cancer agents for efficacy in prevention, intervention and regression. We perform these studies in both xenograft and genetically engineered mouse (GEM) models. The EMSS is a full-service facility, and our team provides technical and scientific expertise to investigators regarding the choice of in vivo model, study design and data collection. In addition to performing in vivo experiments, the EMSS also provides cell culture services such as large upscale cell culture, mycoplasma testing, reduced pricing on media and serum, and transfections of adherent cell lines.
Experimental Timeline
Turnaround time is one to three weeks following discussion with the requesting investigator. While the study is ongoing, updates are provided to investigators weekly via e-mail. Once the experiment is completed, a final report (if requested) is written in a format easily adaptable for submission to most scientific journals. Reports include abstract, introduction, methods, results with tables, graphs, statistical analyses, and discussion sections.
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