Imaging Biomarkers for Cancer Clinical Trials

The shared resource offers standardized MRI imaging protocols for
single-site and multi-site cancer clinical studies. It also offers advanced
image processing to extract quantitative biomarker information from
radiological images. 

DCE-MRI in a Phase I Study of an Anti-Angiogenic Agent. 
A significant decrease in Ktrans was observed in the spleen at the end of a 24 h drug infusion, indicating anti-VEGF activity.

 

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DCE-MRI in a Phase I Study of an Anti-Vascular Agent. 
A significant decrease in Ktrans was observed in the tumor at the end of a 4 h drug infusion. In this study, DCE-MRI showed promise as a pharmacodynamic marker of drug activity.
 
 
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