Science & Biostatistical Collaborations
- Analysis of recurrence of adenomatous polyps in Phase III prevention trial - various statistical models used, including logistic and Poisson with robust variance estimates; investigate viewing the number of adenomas as a latent variable and using mixture distribution (equivalent to zero-inflated Poisson regression); modify zero-inflated Poisson through a weight function to incorporate length of follow-up
- Intermediate markers for cancer prevention trials - karyometric analysis of tissue samples; use of 93 karyometric features captures chromatin information at varying levels of complexity, suggesting the presence of diverse nuclear phenotypes that may be significant for classification or diagnostic purposes (related to malignant progression)
- Design of Phase II clinical trials for innovative targeted therapies
Larger projects
- Colon Cancer Prevention
- Chemoprevention of Skin Cancer
- GI Cancer SPORE
- New Apoptosis Drug Targets
- Apoptosis in Colon Cancer Chemoprevention
- Survival Signals for Molecular Target Assessment
- Targets to Therapeutics in Pancreatic Cancer
Collaborating on AZCC Programs & with AZCC Investigators
- Therapeutic Development Program:
Dorr, Ebbinghaus, Hersh, Hurley, Mahadevan, Miller, Stea, Stopeck
- Cancer Imaging Program:
Bartels, Barton, Gillies, Utzinger
- Cancer Prevention and Control:
Ahmann, Alberts, Chen, Chow, Einspahr, Frank, Garcia, Garland, Hakim, Harris, E. Jacobson, M. Jacobson, Kaemingk, Krouse, Larkey, Lance, Loescher, Lopez, Martinez, Myrdal, Stratton, Swanson, Thomson
- Gastrointestinal Cancer Program:
Akporiaye, Dragovich, Fass, Garewal, Gerner, Ignatenko, Nelson, Payne
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