Randy Burd, PhD

Asst Vice President for Program Innovation, Asst Director of Distance and Global Initiatives, Associate Professor, Bio5 Institute, Nutritional Sciences

E-Mail Address: 
rburd@u.arizona.edu
Phone Number: 
(520) 626-1863
Research Information
Research Program: 
2. Cancer Imaging
Member Status: 
Member
Year of Membership Acceptance: 
2005
Summary of Research Activity: 

Current research interests in our laboratory focus on improving tumor radiation response through the use of biological response modifiers that alter tumor cell function, metabolism, cytokine stimulation and prostaglandin production, and affect aspects of tumor development, growth and treatment response. These include pharmaceutical drugs that are designed to specifically target tumors, bioactive nutritional components such as bioflavonoids, and compounds that regulate tumor glucose metabolism.

Selected Publications: 

1: Mendoza EE, Burd R. Quercetin as a systemic chemopreventative agent: structural and functional mechanisms. Mini Rev Med Chem. 2011 Dec 1;11(14):1216-21. PubMed PMID: 22070678.

2: Mitchell GC, Fillinger JL, Sittadjody S, Avila JL, Burd R, Limesand KH. IGF1 activates cell cycle arrest following irradiation by reducing binding of ΔNp63 to the p21 promoter. Cell Death Dis. 2010;1:e50. PubMed PMID: 21480565; PubMed Central PMCID: PMC2939491.

3: Vargas AJ, Sittadjody S, Thangasamy T, Mendoza EE, Limesand KH, Burd R. Exploiting tyrosinase expression and activity in melanocytic tumors: quercetin and the central role of p53. Integr Cancer Ther. 2011 Dec;10(4):328-40. Epub 2010 Dec 31. PubMed PMID: 21196432.

4: Victory K, Burd R, Fribley A, Sittadjody S, Arnett D, Klein RR, Limesand KH. Head and neck tumor cell radiation response occurs in the presence of IGF1. J Dent Res. 2011 Mar;90(3):347-52. Epub 2010 Nov 12. PubMed PMID: 21076120; PubMed  Central PMCID: PMC3072050.

5: Mitchell G, Fillinger J, Sittadjody S, Avila J, Burd R, Limesand K. IGF1 activates cell cycle arrest following irradiation by reducing binding of ΔNp63 to the p21 promoter. Cell Death Dis. 2010 Jun 10;2010(1):e50. PubMed PMID: 20852680.

6: Grundmann O, Fillinger JL, Victory KR, Burd R, Limesand KH. Restoration of radiation therapy-induced salivary gland dysfunction by post therapy IGF-1 administration. BMC Cancer. 2010 Aug 10;10:417. PubMed PMID: 20698985; PubMed Central PMCID: PMC3087323.

7: Vargas AJ, Burd R. Hormesis and synergy: pathways and mechanisms of quercetin  in cancer prevention and management. Nutr Rev. 2010 Jul;68(7):418-28. PubMed PMID: 20591109.

8: Thangasamy T, Sittadjody S, Mitchell GC, Mendoza EE, Radhakrishnan VM, Limesand KH, Burd R. Quercetin abrogates chemoresistance in melanoma cells by modulating deltaNp73. BMC Cancer. 2010 Jun 11;10:282. PubMed PMID: 20540768; PubMed Central PMCID: PMC2895613.

Collaborative Research: 

Limesand K. H., Hingle M.

Professional Information
Professional Affiliations: 
American Association for Cancer Research
North American Hyperthermia Society
Radiation Research Society
Academic Information
Fellowship: 
NCI Post-Doctoral Fellowship, Thomas Jefferson University, 2001
Doctorate: 
Ph.D., Molecular and Cellular Biophysics, University at Buffalo/Roswell Park Cancer Institute, 1998
Undergraduate School: 
B.A., Biological Sciences, University College at Buffalo, 1994