Matthew A. Kupinski, PhD

Associate Professor

E-Mail Address: 
Phone Number: 
(520) 621-2967
Research Information
Research Program: 
2. Cancer Imaging
Member Status: 
Year of Membership Acceptance: 
Summary of Research Activity: 
I have over 15 years of experience in the field of image science, and I have worked and published on topics including modeling of imaging systems, determination of object statistics, computation of ideal-observer performance, development of adaptive imaging, and assessment of imaging hardware using task-based metrics of image quality, to name a few. I have been a member of the Center for Gamma-Ray Imaging since I was hired as a postdoctoral researcher by the grant in 2000 and am currently an Associate Professor in the College of Optical Sciences and the Department of Medical Imaging. During our last round of funding, we pioneered the field of task-based adaptive imaging, and we have led the way in the development of theory, implementation of adaptive systems and implementation of adaptive methods. The goals of this proposal are challenging and bold and lay out bold new directions for adaptive gamma-ray imaging, which will likely affect other modalities as well. I have a vested interest in every aim of this proposal, and I will actively pursue these
research goals directly, through collaborations and by working with graduate students.
Selected Publications: 

A.K. Jha, H.T. van Dam, M.A. Kupinski and E. Clarkson, “Simulating Silicon Photomultiplier response to scintillation light,” IEEE Transaction on Nuclear Science 60(1): 336-351, 2013. [PubMed - in process]

C. Lee, M. A. Kupinski, L. Volokh, “Assessment of cardiac single-photon emission computed tomography performance using a scanning linear observer,” Medical Physics 40(1):011906, 2013. PMID: 23298097, [PubMed - in process]

A.K. Jha, M. A. Kupinski, T.Masumura, E. Clarkson, A.A. Maslov, H.H. Barrett, “Simulating photontransport in uniform media using the Radiative Transport Equation: A study using the Neumann-series approach,” JOSA A 29(8), 1741-1757, 2012. PMID: 23201893, [PubMed - in process]

A.K. Jha, M. A. Kupinski, H.H. Barrett, E. Clarkson, J.H. Hartman, “Three-Dimensional Neumann-Series for Modeling Light Transport in Nonuniform Media,” JOSA A 29(9): 1885-1899, 2012. PMID: 23201945, [PubMed - in process]

E. Clarkson, R. Palit, M. A. Kupinski, “SVD for imaging systems with discrete rotational symmetry,” Optics Express 18(24): 25306-25320, 2010. PMC3027225

E. Clarkson, M. A. Kupinski, “Global compartmental pharmacokinetic models for spatiotemporal SPECT and PET imaging,” SIAM Journal on Imaging Sciences 2(1), 204-225, 2009. PMC2905890

H. H. Barrett, L. Furenlid, M. Freed, J. Y. Hesterman, M. A. Kupinski, E. Clarkson, M. K. Whitaker, “Adaptive SPECT,” IEEE Transactions on Medical Imaging, 27(6): 775-788, 2008. PMID: 18541485, [PubMed - indexed for MEDLINE]

M. Freed, M. A. Kupinski, L. Furenlid, H. H. Barrett, “A Prototype Instrument for Single Pinhole Small-Animal Adaptive SPECT Imaging”, Medical Physics 35(5):1912-25, 2008. PMC2575412

E. Clarkson, M. A. Kupinski, H. H. Barrett, A Task-Based Approach to Adaptive and Multimodality Imaging,” Proceedings of the IEEE, Invited Paper, 46(3): 500-511, 2008. PMC2597814

J. Y. Hesterman, M. A. Kupinski, E. Clarkson, et al., “Hardware assessment using the multi-module, multiresolution system (M3R) – A signal-detection study,” Medical Physics 34(7): 3034-3044, 2007. PMC2471875

J. Y. Hesterman, M. A. Kupinski, L. R. Furenlid, et al., “The multi-module, multi-resolution system M3R: A novel small-animal SPECT system,” Medical Physics 34(3):987-993, 2007. PMC2517228

M. A. Kupinski, E. Clarkson, H. H. Barrett, “A probabilistic model for the MRMC method, part 2: Validation and applications,” Academic Radiology 13, 1422-1430, 2006.

E. Clarkson, M. A. Kupinski, H. H. Barrett, “A probabilistic model for the MRMC method, part 1: Theoretical development,” Academic Radiology 13(11):1410-1421, 2006. PMC2844793

M. A. Kupinski, John W. Hoppin, Joshua Krasnow, Seth Dahlberg, Jeffrey A. Leppo, Michael A. King, Eric Clarkson, and Harrison H. Barrett, “Comparing Cardiac Ejection Fraction Estimation Algorithms Without a Gold Standard,” Academic Radiology 13(3):329-337, 2006. PMC2464280

M. A. Kupinski, J. W. Hoppin, E. Clarkson, H. H. Barrett, “Ideal Observer Computation Using Markov-Chain Monte Carlo,” Journal of the Optical Society of America A 20, 430-438, 2003.

Bio sketch: