Jiaqi Shi, MD, PhD

Research Assistant Professor

Pathology Resident

E-Mail Address: 
sjq@email.arizona.edu
Short Bio: 

Jiaqi Shi, MD, PhD is currently a Pathology resident and a Research Assistant Professor in Surgery. Dr. Shi received her MD and PhD degrees at Hunan Medical University in China. She then pursued a postdoctoral training at the University of Arizona from 1999 to 2003. Dr. Shi was promoted to Research Assistant Professor in the Department of Pathology in 2003 and to Assistant Professor in Surgery in 2009. Her research interest is translational control in human cancer.  

Clinical Information
Specialty: 
Pathologist
Clinical Focus: 

GI Pathology

Clinical Practice Sites: 
The University of Arizona Medical Center - University Campus
Southern Arizona VA Health Care System
Research Information
Research Program: 
5. Gastrointestinal Cancer
Member Status: 
Associate Member
Year of Membership Acceptance: 
2007
Institution: 
The University of Arizona Cancer Center
College: 
College of Medicine
Summary of Research Activity: 
  • Translational regulation and signaling pathways in pancreatic cancer
  • Identification of new biomarkers and targets for diagnosis and treatment of pancreatic cancer
Selected Publications: 

Shi J, Feng Y, Goulet A-C, Vaillancourt RR, Sachs NA, Hershey JW, Nelson MA. (2003) The p34cdc2 related cyclin-dependent kinase 11 interacts with the p47 subunit of the eukaryotic initiation factor 3 during apoptosis. J. Biol. Chem. 278(7), 5062-5071.

Mikolajczyk M+, Shi J+, Vaillancourt RR, Sachs NA, Nelson M. (2003) The cyclin-dependent kinase 11p46 isoform interacts with RanBPM. Biochem. Biophys. Res. Commun. 310 (1), 14-18 (+ Both authors contributed equally to the paper).

Shi J, Nelson M. (2005) The cyclin-dependent kinase 11 interacts with NOT2. Biochem. Biophys. Res. Commun. 334 (4): 1310-1316.

Baruch AC, Shi J, Feng Y, Nelson MA. (2005) New developments in the staging of melanoma. Cancer Invest. 23 (6): 561-567.

Feng Y, Ariza ME, Goulet AC, Shi J, Nelson MA. (2005) Death-signal-induced relocalization of cyclin-dependent kinase 11 to mitochondria. Biochem. J.  392(Pt 1):65-73.

Shi J, Kahle A, Hershey JW, Honchak BM, Warneke JA, Leong SPL, and Nelson MA. (2006) Decreased expression of eukaryotic initiation factor 3f deregulates translation and apoptosis in tumor cells. Oncogene 25 (35): 4923-4936.

Chandramouli A+, Shi J+, Feng Y, Holubec H, Shanas R, Bhattacharyya AK, Zheng W and Nelson MA. (2007) Haploinsufficiency of the cdc2l gene contributes to skin cancer development in mice. Carcinogenesis 28 (9): 2028-2035. (+ Both authors contributed equally to the paper)

Doldan A, Chandramouli A, Shanas R, Bhattacharyya A, Cunningham JT, Nelson MA, and Shi J. (2008) Loss of the eukaryotic initiation factor 3f in pancreatic cancer. Molecular Carcinogenesis 47 (3): 235-244.

Doldan A, Chandramouli A, Shanas R, Bhattacharyya A, Leong SPL, Nelson MA, and Shi J. (2008) Loss of the eukaryotic initiation factor 3f in melanoma. Molecular Carcinogenesis 47 (10): 806-813.

Shi J, Hershey JW, Nelson MA. (2009) Phosphorylation of the eukaryotic initiation factor 3f by cyclin-dependent kinase 11 during apoptosis. FEBS Lett 583 (6): 971-977.

Zhou R,Shanas R, Nelson MA, Bhattacharyya A and Shi J. (2010) Increased expression of the heterogeneous nuclear ribonucleoprotein K in pancreatic cancer and its association with the mutant p53. Int J Cancer July 16, 126 (2): 395-404 (PMID: 19609950, PMCID: PMC2795109, NIHMSID: NIHMS143874) (*Cover story)

Shi J, Nelson MA . EIF3F (eukaryotic translation initiation factor 3, subunit F). Atlas Genet Cytogenet Oncol Haematol. July 2009.

URL:

http://AtlasGeneticsOncology.org/Genes/EIF3FID44407ch11p15.html

Wen F, Shen A, Shanas R, Bhattacharyya A, Lian F, Hostetter G, and Shi J. (2010) Higher Expression of the Heterogeneous Nuclear Ribonucleoprotein K in Melanoma. Ann Surg Oncol 17 (10): 2619-2627.

Zhou R, Shen A, and Shi J. (2010) The Eukaryotic initiation factor 3 and cancer. Current Topics in Biochemical Research 12 (1): 9-15.
 

Bio sketch: 
application/pdf iconbiosketch2011-general.pdf
Professional Information
Board Certifications: 

Arizona Medical Board

Professional Affiliations: 

Active member, American Association for Cancer Research (AACR)

Member, United States and Canadian Academy of Pathology (USCAP)

Member, Arizona Society of Pathologists

Honors: 

1998 - Second Prize, the 2nd Congress of Science and Technology in the Central District of China

1998 - Excellent Science and Technology Paper Award, Colby Information Center of Science and Culture, Los Angeles, CA

1999 - Cheung Kong Scholars Achievement Award, The Ministry of Education, P. R. China and Li Ka Shing Foundation, Hong Kong

2003 - Arizona Cancer Center’s Most Results Poster Award, University of Arizona

2003 - Bristol-Myers Squibb Oncology Scholar-in-Training Award, American Association for Cancer Research (AACR)

2002-2005 - National Research Service Award, National Institutes of Health

2006-2009 - GI SPORE Career Development Award, NIH/NCI

2011 -  Benjamin Castleman Award, Massachusetts General Hospital and the United States and Canadian Academy of Pathology (USCAP)


2011 -  Best Abstract Award, GoPath Diagnostics/Chinese American Pathologists Association

Academic Information
Residency: 
University of Arizona
Doctorate: 
Hunan Medical University
Medical School: 
Hunan Medical University
Undergraduate School: 
Hunan Medical University