Janiel M. Cragun, MD

Assistant Professor of Gynecologic Oncology

Phone Number: 
(520) 626-0950
Fax: 
(520) 626-9287
Patient Appointments: 
(520) 626-9285
Short Bio: 

Dr. Cragun is an assistant professor at the University of Arizona. She specializes in the diagnosis and treatment of gynecologic cancers such as endometrial and ovarian cancers as well as rare reproductive cancers, abnormal pap smears, high-risk cancer screening and fertility preservation.

Before completing the gynecologic oncology fellowship program at the University of South Florida in Tampa, Dr. Cragun earned her medical degree at the University of Utah School of Medicine, Salt Lake City, Utah; completed a residency in obstetrics and gynecology at Duke University Medical Center, Durham, North Carolina, and pursued a post-doctoral research fellowship at H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida.

Currently, gynecologic cancers account for about 12 percent of all cancers which affect US women. Ovarian cancer alone is the fifth most common cause of cancer death in women. Dr. Cragun’s recent research studies include gene expression in older versus younger women with ovarian cancers responsive to cisplatin, and microRNA associated with development of cisplatin resistance.

Clinical Information
Specialty: 
Gynecologic Oncologist
Clinical Focus: 

Dr. Cragun specializes in the diagnosis and treatment of gynecologic cancers to include:

  • Ovarian Cancer
  • Uterine Cancer
  • Cervical Cancer
  • Vulvar, Vaginal Cancer
  • Gestational Trophoblastic Disease
  • Complicated Gynecologic Surgery
  • Premalignant Conditions of Cervix, Uterus, Vulva
  • Abnormal Pap Smears
  • High-Risk Cancer Screening
  • Fertility Preservation
  • Second Opinions 
Clinical Practice Sites: 
The University of Arizona Cancer Center - North Campus
Research Information
Research Program: 
3. Cancer Biology
Member Status: 
Associate Member
Year of Membership Acceptance: 
2009
Summary of Research Activity: 
  • Investigator initiated trial (PI)      
    The expression of selected micro RNA in cisplatin resistant ovarian cancer cell lines
     
  • 10-0136-04 (GOG 86P)
    Site PI
    A three arm randomized phase II of paclitaxel/carboplatin/bevacizumab, paclitaxel/carboplatin/temsirolimus and ixabepilone/carboplatin/bevacizumab as initial therapy for measurable stage II or IVA, stage IVB, or recurrent endometrial cancer
     
  • 10-0475-10 (GOG 00252)
    Site PI
    A phase III clinical trial of bevacizumab with IV versus IP chemotherapy in ovarian, fallopian tube and primary peritoneal carcinoma 
     
  • Investigator Initiated Trial (Co-PI)
    08-0015-04  Analysis of circulating tumor cells, circulating endothelial cells, and angiogenic factors in patients with breast, cervical, ovarian, and endometrial cancers - an exploratory study
     
  • 10-0254-10 (GOG 0249)
    Co-PI
    A phase III trial of pelvic radiation therapy versus vaginal cuff brachytherapy followed by paclitaxel/carboplatin chemotherapy in patients with high risk, early stage endometrial carcinoma
     
  • 10-0315-04 (GOG 0256)
    Co-PI
    Prospective study of cognitive function during chemotherapy for front-line treatment in ovarian, primary peritoneal or fallopian tube cancer
     
  • 10-0524-04 (SWOG 0904)
    Co-PI
    Randomized phase II study of docetaxel followed by vandetanib vs. docetaxel plus vandetanib in patients with persistent or recurrent epithelial ovarian, fallopian tube, or primary peritoneal carcinoma
Selected Publications: 
Cragun JM.  Screening for Ovarian Cancer.  Cancer Control: J of the Moffitt Cancer Center.  2011; 18(1):16-21.
 
Kamath SG, Chen N, Xiong Y, Wehnam R, Apte S, Humphrey M, Cragun J, Lancaster JM.  Gedunin, a novel natural substance, inhibits ovarian cancer cell proliferation.  Int J Gynecol Cancer.  2009; 19(9): 1564-9.
 
Cragun JM, Ellestad SC, Panni MK. Aminiotic fluid embolism presenting after uterine manipulation under general anesthesia: a case with a positive outcome. Resuscitation. 2008; 77(1): 145-6.
 
Strosberg J, Nasir A, Cragun J, Gardner N, Kvols L. Metastatic carcinoid tumor to the ovary: A clinicopathologic analysis of seventeen cases. Gynecologic Oncology. 2007; 106(1): 65-8.
 
Dressman HK, Berchuck A, Chan G, Zhai J, Bild A, Sayer R, Cragun J, Clarke J, Whitaker RS, Li L, Gray J, Marks J, Ginsburg GS, Potti A, West M, Nevins JR, Lancaster JM. An intergrated genomic-based approach to individualized treatment of patients with advanced-stage ovarian cancer. Journal of Clinical Oncology. 2007; 35(5): 517-25.
 
Havrilesky LJ, Cragun JM, Calingaert B, Alvarez Secord A, Valea FA, Clarke-Pearson DL, Berchuck A, Soper JT. The prognostic significance of positive peritoneal cytology and adnexal/serosal metastasis in stage IIIA endometrial cancer. Gynecologic Oncology. 2007; 104(2): 401-5.
 
Lancaster JM, Dressman HK, Clare JP, Sayer RA, Martino MA, Cragun JM, Henriott AH, Gray J, Sutphen R, Elahi A, Whitaker RS, West M, Marks JR, Nevins JR, Berchuck A. Identification of genes associated with ovarian cancer metastasis using microarray expression analysis. International Journal of Gynecologic Cancer. 2006; 16(5): 1733-45. 
 
Lutman CV, Havrilesky LJ, Cragun JM, Secord AA, Calingaert B, Berchuck A, Clarke-Pearson DL, Soper JT. Pelvic lymph node count is important prognostic variable for FIGO grade I and II endometrial carcinoma with high-risk histology. Gynecologic Oncology. 2006;102(1): 92-7.
 
Havrilesky LJ, Cragun JM, Calingaert B, Synan I, Secord AA, Soper JT, Clarke-Pearson DL, Berchuck A. Resection of lymph node metastasis influence survival in stage IIIC endometrial cancer. Gynecologic Oncology. 2005; 99(3): 689-95.
 
Martino M, Balar A, Cragun JM, Hoffman MS. Delayed treatment of invasive cervical cancer due to intimate partner violence. Gynecologic Oncology. 2005; 99(2): 507-9.
 
Chen L, Li L, Goldgof D, George F, Chen Z, Rao A, Cragun J, Sutphen R, Lancaster J. Improving reliability of response prediction to platinum-based therapy by AdaBoost and multiple classifiers. Conf Proc IEEE Eng Med Biol Soc. 2005; 5: 4822-5.
 
Li L, Chen L, Goldgof D, George F, Chen Z, Rao A, Cragun J, Sutphen R, Lancaster J. Integration of clinical information and gene expression profiles for prediction of chemo-response for ovarian cancer. Conf Proc IEEE Eng Med Biol Soc. 2005; 5: 4818-21.
 
Cragun JM, Havrilesky L, Calingaert B, Synan I, Secord A, Soper J, Clarke-Pearson D, Berchuck A. Retrospective Analysis of Selective Lymphadenectomy in Apparent Early-Stage Endometrial Cancer. Journal of Clinical Oncology. 2005; 23(16): 3668-75.
Professional Information
Board Certifications: 

South Carolina Medical License, active, 2004

Florida Medical License, active, 2005

Arizona Medical License, active, 2008

The American Board of Obstetrics and Gynecology, Inc., Diplomate, 2010

Professional Affiliations: 

American College of Obstetricians and Gynecologists, active, 2003

American Society of Clinical Oncology, Active, 2005

Society of Gynecologic Oncologists, active, 2007

Honors: 

1st place, Amgen Young Investigator Forum, Joint Cancer Conference of the Florida Universities, Orlando, FL, 2005

Academic Information
Fellowship: 
University of South Florida, Tampa, FL - Gynecologic/Oncology, 2008
Residency: 
Duke University Medical Center, Durham, NC - Obstetrics/Gynecology 2004
Medical School: 
University of Utah, Salt Lake City, UT - MD, 2000
Master's Degree: 
Utah State University, Logan, UT - MSS Human Resource Management, 1996
Undergraduate School: 
Utah State University, Logan, UT - BA Liberal Arts and Sciences (magna cum laude), 1992